Biosafety levels canada , CL1, CL2, CL3, CL4) EAD Emerging animal disease ERP Legal basis. The guideline outlines the steps essential to the development and execution of a comprehensive biosafety program, which includes planning, implementing, reviewing, and improving the program. NAME: Herpes simplex virus SYNONYM OR CROSS REFERENCE: HSV-1, HSV-2, HHV-1, HHV-2, Human herpes virus 1, Human herpes virus 2, cold sores, fever blisters Footnote 1, Footnote 2. NAME: Human rotavirus. , boot or shoe covers) where floors Therefore, the level of containment necessary for working safely with bacterial cultures also varies according to a system that classifies microbes into one of four biosafety levels (BSL), which provides minimum standards for safe handling of microbes at each level. Containment Level 2 Laboratory: Safety Procedures. This guideline provides the foundation upon which all the biosafety requirements for Containment Levels 2 through 4, as outlined in the Canadian Biosafety Standard (CBS), are established. This guideline provides risk-based biosafety practices for facilities where Risk Group 1 (RG1) biological material is handled. The e-mail was a follow-up to a phone conversation on July 22, 2002, regarding the WESTERN UNIVERSITY BIOSAFETY POLICIES AND PROCEDURES MANUAL . absa. - In Canada: the four levels are known as Containment Levels. In the early 1980s, only two such laboratories existed in North America, one at the Centers for Disease Control and Prevention (CDC) in Atlanta, GA, and the other at the U. , facilities licensed under the Human Pathogens and Toxins Act [HPTA] or importing under the Health of Animals Act [HAA] and Health of Animals Regulations [HAR]) are required to develop a Biosafety directives. Where applicable, the Canadian Biosafety Guidelines will be updated to align with the Canadian Biosafety Standard, Third Edition. 1 Public Health Agency of Canada (PHAC) 1. A mitigation measure will protect one or multiple assets; with this in mind, the CONTAINMENT REQUIREMENTS: Biosafety Level 2 practices, containment equipment and facilities for activities involving known or potentially infectious materials, including necropsy of infected animals. NAME: Naegleria fowleri. Work in small animal containment zones (SA zones) must meet the applicable requirements in the CL3 column of the CBS, whereas work in large animal containment zones (LA zones) must Spores of Clostridium species can be killed by high level disinfectants such as 2% aqueous glutaraldehyde within 3 hours, as well as an overarching risk assessment of the biosafety program as a whole. CHARACTERISTICS: Lactobacillus species are members of the Lactobacillaceae family Footnote 1. 1. (B. This will assist in determining appropriate mitigation measures that reduce site 4 days ago · PATHOGEN SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT. The threat of terrorists using as weapons the most deadly pathogens known, coupled with the recognition that virtually every year a new infectious disease is discovered, has led the US government to expand the number of Biosafety Level 4 (BSL-4) laboratories, also known as maximum containment laboratories (MCLs), to perform work essential for promoting public The uOttawa Biosafety Program has conducted a training needs assessment, which determined the different levels of training to be taken by the RG1 (non-regulated material) users and the RG2/3 users. Biosecurity. Biological Safety Level 3 (BSL-3) laboratories are designed to safely handle pathogens that pose serious health risks through inhalation, such as Mycobacterium tuberculosis, SARS-CoV-2, and West Nile virus. Viral replication can be inhibited by nucleoside analogues which can reduce or terminate viral shedding, but have no effect on the symptoms Footnote 1 Footnote 4. 1 Scope. Washington, D. Page details Date modified: 2014-03-28. It is for these reasons that control of biological risks typically begins at the national level, Canadian Biosafety Guideline - Containment Level 1: Physical Design and Operational Practices Canadian Biosafety Guideline - Containment Level 1: Physical Design and Operational Practices This guideline describes the general recommendations and considerations for basic laboratory design and the safe handling of RG1 biological material; these Containment Level 3 facilities, equipment, and operational practices outlined in the Canadian Biosafety Standard for work involving infectious or potentially infectious materials, animals, or cultures. Richmond, & R. All facilities, including containment level 2 (CL2), that are subject to the Canadian Biosafety Standard (CBS), 2 nd Edition (i. This guideline provides risk-based recommendations for facilities handling RG1 biological material, which is either not capable of, PATHOGEN SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT. Army Medical Research Institute of Infectious Diseases Jan 6, 2025 · From the perspective of the history of science and technology, this paper delves into the global development of high-level biosafety laboratories, the establishment of related legal frameworks, and the evolution of safety standards. The Government of Canada accepts no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the The lowest of the four biosafety levels, biosafety level 1 (BSL-1) applies to laboratory settings in which personnel work with low-risk microbes that pose little to no threat of infection in healthy adults — for example, a BSL-1 PATHOGEN SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT. Public Health Agency of Canada Licence: Open Government Licence - Canada; Data and Resources Canadian Biosafety Handbook, Second Edition HTML. 3 The Biosafety Footnote 16 sGP is released at high levels during illness and acts as a decoy to inhibit the protective humoral response by binding to ebolavirus-neutralizing antibodies. pathogenic or infections organisms) that pose a moderate health hazard. 1%) or sharps-related incidents (15. CHARACTERISTICS: The ameboid form of Naegleria fowler is Sep 7, 2021 · laboratories are considered to be fundamental agents of biosafety (and biosecurity). SYNONYM OR CROSS REFERENCE: HBV Footnote 1-Footnote 11, hepatitis B Footnote 1, HBV infection Footnote 1-Footnote 3 Footnote 11, type B hepatitis Footnote 4 Footnote 12 Footnote 13, serum hepatitis, homologous serum jaundice, Biosafety Level 1 is suitable for work involving well-characterized agents not known to consistently cause disease in healthy adult humans, and of minimal potential hazard to laboratory personnel and the environment. www. Davey, L. Containment Level 2 Operational Practices. Laboratories working with non Canadian Biosafety Guideline - Containment Level 1: Physical Design and Operational Practices Canadian Biosafety Guideline - Containment Level 1: Physical Design and Operational Practices This guideline describes the general recommendations and considerations for basic laboratory design and the safe handling of RG1 biological material; these recommended practices are 1. The pathogen risk assessment determines the inherent risk of the pathogen, expressed in terms of The applicable Containment Level 3 requirements for personal protective equipment and clothing outlined in the Canadian Biosafety Standard to be followed. Feldmann); Boston University School of Medicine, Boston, Massachusetts, USA (J. Y. The Public Health Agency of Canada (PHAC) the common education level was a technical or trades college diploma (42. NAME: Hepatitis B virus (HBV). CHARACTERISTICS: Enterotoxigenic Escherichia coli (ETEC) are in the family Laboratory Biosafety and Biosecurity. The Canadian Biosafety Handbook is currently being updated to align with the Canadian Biosafety Biosafety advisory from the Public Health Agency of Canada (PHAC) to assist clinical, diagnostic, and research laboratories implement proper biosafety procedures to safely handle materials that may contain the monkeypox virus (MPXV) The Canadian Food Inspection Agency works with Agency scientists and technical experts to establish the biocontainment levels, procedures and protocols that are needed to work safely with animal and zoonotic pathogens, chemical hazards, and plant pests of quarantine significance, and to protect laboratory staff, the Canadian public, and the environment. Biomedical laboratories can also have an important part to play in building in-country biological risk management capacity and promoting a culture of responsibility. NAME: Clostridium tetani. This biosafety level covers laboratories that work with agents associated with human diseases (i. Biohazardous Agents Risk Assessment. anthracis strains, respectively. Risk Assessments. CHARACTERISTICS: Enterotoxigenic Escherichia coli (ETEC) are in the family The applicable Containment Level 3 requirements for personal protective equipment and clothing outlined in the Canadian Biosafety Standard to be followed. - In the European Union: the same biosafety levels are defined in a Directive. [5] Essential features of a biosafety level 4 (BSL-4 The Biosafety Level 4 Zoonotic Laboratory Network (BSL4ZNet) is a network of animal and public health organizations from Australia, Canada, Germany, the United Kingdom and the United States. This update presents information provided by Robert C. Belgian level: - Decree of the Flemish Region (6 February 2004) - Decree of the Walloon Region (4 July 2002) - Decree of the Brussels-Capital Region (8 November 2001) EU level:-Directive 2009/41/EC on the contained use of genetically modified micro-organisms (and subsidiary decisions)- Directive 2000/54/EC on the protection of workers from risks related to PATHOGEN SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT. , using, storing, importing) with human pathogens that are classified as Risk Group 2-4, or with toxins listed in Schedule 1 of the HPTA, require a licence, issued by Construction of several new Biosafety Level 4 (BSL-4) laboratories and expansion of existing operations have cre-ated an increased international demand for well-trained staff USA (M. Laboratories receiving specimens from patients under investigation for Ebola Disease must be aware that improper handling of these specimens poses serious risk to the health of laboratory personnel. The importance of these laboratories within the context of national security is emphasized. Dec 27, 2012 • ericminikel. Search our Collections & Repository. RISK GROUP CLASSIFICATION: Risk Group 2 (). Biosafety directives provide regulated parties with the customized containment requirements for activities with a specific pathogen or group of pathogens when the containment level does not align with the risk group. S. , CL3 large animal containment zone) EAD Emerging animal disease FAD Foreign animal disease HAA May 21, 2024 · Biosafety and Biosecurity), Canada Dr Catherine Makison Booth, Health and Safety Executive, United Kingdom of Great Britain and Northern Ireland Ms Michelle McKinney, Centers for Disease Control and Prevention (WHO Collaborating Centre for Biosafety and Biosecurity), and National Institutes of Health, Jan 7, 2025 · The uOttawa Biosafety Program has conducted a training needs assessment, which determined the different levels of training to be taken by the RG1 (non-regulated material) users and the RG2/3 users. They may, but don't always, align with Canadian RG classifications and CL requirements. fumigatus, A. Human stool, soil Containment Level 2 facilities, equipment, and operational practices outlined in the CBS for work involving infectious or potentially infectious materials, animals, 1 day ago · More information on medical surveillance is available in the Canadian Biosafety Handbook . Pathogen Safety Data Sheets: Infectious Substances Section I - Infectious Agent. The BSL4ZNet aims to enhance preparedness for current and future emerging pathogens In most cases, risk group classification is indicated at the species level; however, in some cases, genus-level and strain-level classifications are listed. The applicable Containment Level 2 requirements for personal protective equipment and clothing outlined in the CBS are to be followed. SYNONYM OR CROSS REFERENCE: HBV Footnote 1-Footnote 11, hepatitis B Footnote 1, HBV infection Footnote 1-Footnote 3 Footnote 11, type B hepatitis Footnote 4 Footnote 12 Footnote 13, serum hepatitis, The biosafety handbook on safe and secure handling of pathogens and toxins in Canada. (2015). Use this guideline in conjunction with the Canadian Biosafety Standard. In order to allow the on-demand training and reduce the training process by 50%, we are now migrating to the Public Health Agency of Canada’s Aug 27, 2019 · series of electronic publications that expand upon the biosafety and biosecurity concepts discussed in the current edition of the Canadian Biosafety Handbook (CBH), the companion document to the Canadian Biosafety Standard (CBS). SYNONYM OR CROSS REFERENCE: CHIKV Footnote 1-6, CHIK Footnote 2 Footnote 7-9, and chikungunya fever Footnote 2 Footnote 10. SYNONYM OR CROSS REFERENCE: Cryptosporidiosis Footnote 1 Footnote 2, crypto. PATHOGEN SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT. Version 2. Airway obstruction is treated with a high dose of corticosteroid and nasopharyngeal airway Footnote 1 Footnote 4 Footnote 9. 4 Biosafety Lab Levels Infographic. CHARACTERISTICS: HSV virus, types 1 and 2, belong to the sub family Alphaherpesviridae Updates on biosafety and biosecurity for 2021, Q3. , CL1, CL2, CL3, CL4) ERP Emergency response plan IBC Institutional biosafety The Public Health Agency of Canada (PHAC) regulates human pathogens and toxins under the authority of the Human Pathogens and Toxins Act (HPTA) and associated Regulations (HPTR). NAME: Cryptosporidium parvum. Jan 7, 2025 · The Biosafety Level 4 Zoonotic Laboratory Network (BSL4ZNet) developed a rapid collaborative response for COVID-19. perfringens is usually CONTAINMENT REQUIREMENTS: Biosafety Level 2 practices, containment equipment and facilities for activities involving known or potentially infectious materials, including necropsy of infected animals. Mckinney (Eds. This paper begins with an overview of global high 5 days ago · Containment Level 2 facilities, equipment, and operational practices outlined in the Canadian Biosafety Standard for work involving infectious or potentially infectious materials, animals, or cultures. Gloves when direct In the European Union, the same biosafety levels are defined in a directive. pallidum cells die readily upon desiccation or exposure to atmospheric levels of oxygen Footnote 24. What are Cells and Cell Lines? In the context of the HPTA, cells or cell lines are derived from a human or animal source and can also be produced or cultured. See more Information on biosafety standards, training, pathogen hazards, exposure reporting, registration, permits, containment and operational requirements. 1 Western University Health and Saf ety Policy 4 1. , pp. D. The handling or storing of infectious material or toxins necessitates an awareness and application of biosafety and biosecurity practices among Jun 18, 2024 · The principle of biosafety levels (BSLs) is to provide a series of containment levels that correspond to the increasing risk of exposure to infectious agents. Today, the Honourable Jane Philpott, Minister of Health, announced a reconfiguration project at the Canadian Science Centre for Human and Animal Health that will convert existing laboratory space to the highest level of biosafety - CL4. SYNONYM OR CROSS REFERENCE: Tetanus Footnote 1 ; Lockjaw Footnote 2 . 2009, c. First aid/treatment. 0 . SYNONYM OR CROSS REFERENCE: Lactobacillus, lactobacillemia Footnote 1 Footnote 2. The gram 4. NAME: Lactobacillus spp. They are also inactivated by heat treatment at 56°C in 10% rabbit serum for 30 minutes Footnote 34 and by dissolution in 65% InterSol platelet additive solution Laboratory Biosafety and Biosecurity. , using, storing, importing) with human pathogens that are classified as Risk Group 2-4, or with toxins listed in Schedule 1 of the HPTA, require a licence, issued by The last national peak of pertussis infection in Canada occurred in 1998 Footnote 7. Refer to the Help section for more detailed instructions. These Pathogen Safety Data Sheets, regulated under Workplace Hazardous Materials Information System (WHMIS) legislation, are produced for personnel working in the life sciences as quick safety reference material relating to infectious micro-organisms. The personal protective equipment could include the use of a labcoat and dedicated footwear (e. CHARACTERISTICS: S. , Leitner R. Canadian Biosafety Standard (CBS) (2nd ed. 0 Additional Biosafety Requirements. In J. To ensure the safety of researchers, the environment, and the PATHOGEN SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT. This $5 million project will reconfigure adjacent high containment lab areas within the existing footprint of the building. PROTECTIVE CLOTHING: Laboratory coat; gloves when contact with infectious materials is unavoidable. g. Biosafety Level 4 (BSL-4) Biosafety level 4 is the highest level that is employed while working with dangerous infectious agents that present a high individual as well as environmental risk in the form of life-threatening EC member, Canadian Consortium of Academic Biosafety Level 3 Laboratories (CCABL3) Canada Research Chair in Translational Vaccinology and Inflammation Professor, Department of Microbiology and Immunology, Dalhousie University. CHARACTERISTICS: Cryptosporidium parvum is an intracellular protozoan parasite of the family Cryptosporidiidae and phylum Apicomplexa Footnote 1 Footnote 3. Ebolavirus virions enter host cells through endocytosis and replication occurs in the cytoplasm. It is for these reasons that control of biological risks typically begins at the national level, 2 days ago · PATHOGEN SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT. terreus Footnote 1. [4] Facilities with these designations are also sometimes given as P1 through P4 (for pathogen or protection level), as in the term P3 laboratory. Containment Level 1: Operational Practices . In addition to the requirements listed for CL2 and CL3 specified in Chapters 3, 4, and 5 of the CBS, the requirements below (designated as 'CBS R' followed by the requirement number) are to be followed for activities listed in Table 1 as requiring CL2 with additional biosafety requirements (Footnote a) or CL3 (Footnote b). PROTECTIVE CLOTHING: Laboratory coat; gloves should be worn during necropsy of infected animals and when contact with infectious materials is PATHOGEN SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT. CHARACTERISTICS: A member of the Togaviridae family Footnote 4 Footnote 10 Footnote Key Features and Requirements of Biosafety Level 3 (BSL-3) Laboratories. The broadest is the overarching risk assessment, which encompasses risk management and mitigation strategies that apply to the biosafety program as a whole. SYNONYM OR CROSS REFERENCE: Primary amoebic meningoencephilitis (PAM) Footnote 1, Footnote 2, brain eating amoeba Footnote 3, naegleriasis Footnote 4. The Canadian Biosafety Standard (CBS) sets out the requirements for Canadian containment facilities handling human and/or animal pathogens and toxins. coli Footnote 2, enteric pathogen Footnote 2. Similarly, in Europe countries, the biosafety levels are defined in a ‘directive’ and in Canada, as ‘containment levels’. They are gram positive rods or coccobacilli and RG or biosafety level (BSL) classifications published by other organizations (for example, culture collections, distributors, manufacturers, and other countries) have no regulatory significance under the HPTA and HPTR. Aerosols forming during standard lab procedures like pipetting, mixing, and centrifuging poses the greatest The applicable Containment Level 2 or Containment Level 3 requirements for personal protective equipment (PPE) and clothing outlined in the CBS to be followed for work involving RG2 and RG3 B. CL2 with additional operational practices as outlined in the Biosafety Directive for New and Emerging Influenza A Viruses. These resources may be used as part of a facility’s biosafety and biosecurity training program for new and existing employees, every facility is The biosafety handbook on safe and secure handling of pathogens and toxins in Canada. 1. The handling and storing of pathogens and toxins poses a risk to public health, animal health, or both. melitensis, B. ). Since January 2020, the BSL4ZNet has held biweekly meetings with all partner organizations to provide a space How to use this tool How to use this tool. The CBS describes the three containment levels recognized by the PHAC and the CFIA, ranging from the lowest level permitted to work with regulated materials (i. Sources/specimens. 1 day ago · More information on medical surveillance is available in the Canadian Biosafety Handbook . Publisher - Current Organization Name: Public Health Agency of Canada Licence: Open Government Licence - Canada Jan 7, 2025 · CONTAINMENT REQUIREMENTS: Biosafety level 2 practices, containment and facilities for activities involving the manipulation of known or potentially infectious tissues, body fluids and the housing of infected animals (for all serovars) Apr 21, 2015 · The EWG included 21 members with expertise in the field of biosafety or biocontainment, representing a wide range of sectors (i. NAME: Brucella spp. Table of Contents Page # 1. Activities in Canada involving human and animal pathogens and toxins are regulated by the Public Health Agency of Canada (PHAC) and the 4 days ago · PATHOGEN SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT. In the United States, the CDC has defined 4 different biosafety levels for handling biological materials of different risk levels. At minimum, use of full body coverage dedicated protective clothing, dedicated protective footwear and/or additional protective footwear, gloves when handling infectious materials or animals, face protection when there is a known or In 2016, Canada took a leading role in addressing global bio-surveillance capabilities and established the Biosafety Level 4 Zoonotic Laboratory Network (BSL4ZNet), with an objective to strengthen international coordination and improve knowledge sharing. abortus, B. Canada’s only CL4 labs are found in Winnipeg, Manitoba, at the Canadian Science Centre for Human and Animal Health (CSCHAH). and Ugwu K. pneumoniae is of the Streptococcaceae family. Advanced Biosafety in the Laboratory covers biosafety level 1 (BSL1) and biosafety level 2 (BSL2) environments, with minimal introduction to biosafety level 3 (BSL3). The applicable Containment Level 2 requirements for personal protective equipment and clothing outlined in the Canadian Biosafety Standard are to be followed. Each level defines specific laboratory practices, safety equipment, and facility design requirements to safely handle pathogens and protect laboratory personnel and the environment. Chapter 1 - Introduction 1. The laboratory is not necessarily separated from the general traffic patterns in the building. Facilities with these The biosafety handbook on safe and secure handling of pathogens and toxins in Canada. org Applied Biosafety Vol. , CL1, CL2, CL3, CL4) HAA Health of The Public Health Agency of Canada (PHAC) regulates human pathogens and toxins under the authority of the Human Pathogens and Toxins Act (HPTA) and associated Regulations (HPTR). can be killed by high level disinfectants such as 2% aqueous (2004). NAME: Chikungunya virus. [3] In Canada the four levels are known as Containment Levels. Biology professors, teachers, and anyone who works with live animals, viruses or microorganisms will benefit from this one-day professional development course. 24. SYNONYM OR CROSS REFERENCE: Pneumococcus, diplococcus, pneumococcal pneumonia, bacteremia, acute sinusitis, acute otitis, meningitis. Dragon . It was established to respond to current and emerging high-consequence bio-threats using a One Health approach, The Human Diagnostic Activities guideline was developed by the Public Health Agency of Canada (PHAC) as part of a series of electronic publications that expand upon the biosafety and biosecurity concepts discussed in the current edition of the Canadian Biosafety Handbook (CBH), the companion document to the Canadian Biosafety Standard (CBS CONTAINMENT REQUIREMENTS: Biosafety level 2 practices, containment equipment and facilities for activities involving cultures and infected clinical materials. C. CHARACTERISTICS: The genus Aspergillus belongs to the class Euascomycetes of the Phylum Ascomycota The Biosafety Level 4 Zoonotic Laboratory Network (BSL4ZNet) is a network of animal and public health organizations from 5 countries. industry, academia, and public health) and various levels of government. There are four containment levels ranging from a basic laboratory for work with biological material (i. Canada: Public Health Agency of Canada. Containment Level 2 facilities, Bacterial Agents. , Containment Level 1 [CL1]) to the highly sophisticated facilities for work with the highest risk pathogens (i. Baldwin, 1943 Who became the director of Camp Detrick and when Figure 1: The Government of Canada’s biosafety and biosecurity document hierarchy Incident Investigation was developed by the PHAC and the CFIA as part of a series of electronic CL Containment level (i. Treatment is mainly supportive for infants with mild disease; however, Containment Level 2 facilities, equipment, and operational practices outlined in the CBS for work involving infectious or potentially infectious materials, 2 days ago · The Public Health Agency of Canada (PHAC) regulates human pathogens and toxins under the authority of the Human Pathogens and Toxins Act (HPTA) and associated Regulations (HPTR). 1 Health, Safety and Wellness 4 1. Please note that modification of biological agents, both natural and engineered, may change the risk group classification. Jamou, Ph. Health Canada Également disponible en français sous le titre Lignes directrices en matière de biosécurité en laboratoire In Canada, syphilis is the third most reported notifiable sexually transmitted and blood borne infection (STBBI), T. These mean different requirements as to what containment practices have to be used in order to work safely with those materials. NAME: Staphylococcus aureus. Bloom); Public Health Agency of Canada, Win-nipeg, Manitoba, Canada (H. , Biotechnology Advisor for the National Institutes of Health (NIH) Office of Biotechnology Activities. , CL2) to the highest level In Canada the four levels are known as Containment Levels. NAME: Escherichia coli, enterotoxigenic. General Safety for Containment Labs. Examples of agents typically worked with in a BSL-2 include equine encephalitis viruses and HIV, as well as Staphylococcus aureus (staph infections). C. SYNONYM OR CROSS REFERENCE: Aspergillosis, farmer's lung, A. The CBS outlines physical containment, operational practice, and performance In Canada, facilities where Risk Group 2, 3, and 4 human pathogens or toxins are handled and stored are regulated by the Public Health Agency of Canada (PHAC) under the Human In Canada, facilities where Risk Group 2, 3, and 4 human pathogens or toxins are handled and stored are regulated by the Public Health Agency of Canada (PHAC) under the Human Canadian biosafety standard for facilities handling or storing human and terrestrial animal pathogens and toxins . [4] . Always consult the ePATHogen database to determine the RG and CL of your Biosafety Guidelines 3rd Edition Published by authority of the Minister of Health Population and Public Health Branch Centre for Emergency Preparedness and Response. The CDC defines risk assessment as the process by which the appropriate Containment Level 2 facilities, equipment, and operational practices outlined in the Canadian Biosafety Standard for work involving infectious or potentially infectious materials, animals, or cultures. PROTECTIVE CLOTHING: Lab coat. BSLs are defined and containment practices are detailed by the Centers for Dec 6, 2024 · WESTERN UNIVERSITY BIOSAFETY POLICIES AND PROCEDURES MANUAL . From: Public Health Agency of Canada Overview. (Health Canada The Containment Level 1: Physical Design and Operational Practices guideline was developed by the PHAC and the CFIA as part of a series of electronic publications that describe biosafety and biosecurity concepts in Canada. WESTERN UNIVERSITY BIOSAFETY POLICIES AND PROCEDURES MANUAL . Food poisoning caused by C. , Graham M. OTHER PRECAUTIONS: Good personal hygiene and frequent handwashing essential Several types of risk assessment are performed to support the biosafety program within an organization. 9 Institutional Level Biosafety Training Containment Level 3 facilities, equipment, and operational practices outlined in the Canadian Biosafety Standard and in the Biosafety advisory: SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) for all in vivo and in vitro activities. Objectives Mar 31, 2023 · Canadian Biosafety Handbook CBS Canadian Biosafety Standard CFIA Canadian Food Inspection Agency CL Containment Level (i. CHARACTERISTICS: Bordetella pertussis are small, gram-negative, encapsulated, non-motile, coccobacilli with BIOSAFETY LEVEL 1 • Biosafety level 1 is suitable for work involving well characterized agents not known to consistently cause disease in healthy adult humans and of minimal potential hazard hosted by the CBD Biosafety Level 2 (BSL-2) containment is generally required for work with this vector. The personal protective equipment could include the use of a This guideline is based on the biosafety standards developed by the Public Health Agency of Canada (PHAC) and the Canadian Food Inspection Agency (CFIA) as discussed in the Canadian Biosafety Guideline – Containment Level 1: Physical Design and Operational Practices (2017) (CBG) and the Canadian Biosafety Handbook (CBH) 2nd edition, 2015. In December 2014, the National Academies of Sciences convened the first of 2 meetings to discuss the potential risks and benefits of so-called gain-of-function (GOF) research, which was defined by the National Scientific Advisory Board for Biosecurity as research toward increasing the transmissibility, pathogenicity, or ability to evade countermeasures of pathogens with As of April 1, 2023, the Canadian Biosafety Standard, Second Edition (CBS2), referenced in this document, is no longer in effect. Its 2 days ago · SECTION I - INFECTIOUS AGENT. Contact the Public Health Agency of Canada if you need assistance: Phone: 1-613 laboratories are considered to be fundamental agents of biosafety (and biosecurity). The CDC defines risk assessment as the process by which the appropriate selection of practices and safe Oct 25, 2016 · The number of biosafety level 4 (BSL4) maximum-containment laboratories (facilities) worldwide has increased significantly. Administer proper drug therapy. Section II: Hazard identification Pathogenicity and toxicity. Canada has one BSL4 facility CONTAINMENT REQUIREMENTS: Biosafety level 2 practices for activities involving clinical materials of human or animal origin; Health Canada, 2001. Return to footnote 1 referrer. For Containment Level 1 & 2 Laboratories . SYNONYM OR CROSS REFERENCE: HRV, Human reovirus-like agent, infantile gastroenteritis virus Footnote 1, sporadic viral gastroenteritis, severe viral gastroenteritis of infants and children, non-bacterial gastroenteritis of infancy, and 2 days ago · This document is intended to support local risk assessments, specifically for a diagnostic laboratory setting. NAME: Bordetella pertussis SYNONYM OR CROSS REFERENCE: Originally named Haemophilus pertussis F Footnote 1, Whooping cough Footnote 2. The level of aggregation should be at the group or component level; Table 5-4 provides an example output table for this assessment up to the group level. Biosafety. Safe handling of human and animal pathogens, toxins and plant pests in laboratories and containment zones. , CL4). Return to footnote 25 referrer. SYNONYM OR CROSS REFERENCE: ETEC Footnote 1 Footnote 2, intestinal pathogenic E. These labs also contain biosafety cabinets which protect from pathogen exposure. (1999). flavus, A. About this site. 2. The Conducting a Biosecurity Risk Assessment guideline provides a methodology for assessment of 4 days ago · Note: Please consult the Canadian Biosafety Standard and CBH for additional details on requirements for reporting exposure incidents. First aid/treatment: Treatment of infectious mononucleosis is mainly supportive Footnote 4. nidulans, A. Price and D. Return to footnote 27 referrer. 4, 2007 239 for autopsies, or for examination of contaminated bodies at a BSL-3 or 4 level setting; to do so at Spores of Clostridium spp. . , CL1, CL2, CL3, CL4) CL2-Ag CL2 Agriculture (i. It has a complex lifecycle Biosafety levels for dealing with prions. In these cases, a pathogen risk assessment must be conducted. The descriptions of biosafety levels (BSL) 1 – 4 parallel those in the NIH Guidelines for Jan 6, 2025 · As described in the Canadian Biosafety Guideline: Human Diagnostic Activities, facilities are encouraged to conduct a local risk assessment (LRA) for diagnostic activities, taking into consideration the potential for infectious aerosol and droplet production and the risk of exposure. ), Laboratory Biosafety Guidelines (3rd ed. E. S. Speakers will include scientists from government, academia and industry. such as those found in the Canadian Biosafety Standard, may be incomplete and are specific to the Canadian context. niger, A. Pathogens worked on in CL2 labs are mostly spread through injection or ingestion Basic laboratories – Biosafety Levels 1 and 2 9 Code of practice 9 Laboratory design and facilities 12 Laboratory equipment 14 Health and medical surveillance 16 Consultant in Biosafety, Ashton, Ontario, Canada Ms Margery Kennett, Victorian Infectious Diseases Reference Laboratory, North Mel-bourne, Australia (retired) Containment Level 2 facilities, equipment, and operational practices outlined in the Canadian Biosafety Standard for work involving infectious or potentially infectious materials, animals, or cultures. Updates on biosafety and biosecurity for 2021, Q3. In order to allow the on PATHOGEN SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT. BIOSAFETY PROGRAM FRAMEWORK 4 . , Ouellette M. Footnote 28. Figure 1: The Government of Canada's Biosafety and Biosecurity Document Hierarchy Text Equivalent. 1%) most exposures occurred through inhalation (56. Abstract. Biological Agents. (Eds. Controlled activities (e. English CONTAINMENT LEVELS; CONTAINMENT ZONES; RISK FACTORS; RISK GROUPS; RISK ASSESSMENTS; Biosafety levels dictate the type of work practices that are allowed to occur in a lab setting and play a huge role in the design of the facility. Page details Date modified: 2011-02-18. 12, No. , CL2-Ag, CL3-Ag) BSC Biological safety cabinet BSO Biological safety officer CBH Canadian Biosafety Handbook CBS Canadian Biosafety Standard, Third Edition CFIA Canadian Food Inspection Agency CL Containment level (i. , using, storing, importing) with human pathogens that are classified as Risk Group 2-4, or with toxins listed in Schedule 1 of the HPTA, require a licence, 3 days ago · The applicable Containment Level 2 requirements for personal protective equipment and clothing outlined in the Canadian Biosafety Standard are to be followed. 8%) SECTION VII - EXPOSURE CONTROLS / PERSONAL PROTECTION . W. 2 Regulation of Biological Agents within the University 5 1. for use and storage of biological materials . These labs are called Containment Level 4 labs (CL4). The Government of Canada's Canadian Biosafety Standard (CBS), 4. Risk assessment plays an important role in determining the biosafety level of a lab. Public Health Agency of Canada. canis, B. These resources will help you minimize biosafety risks and promote compliance with the Human Pathogen and Toxins Act and Regulations, and with the Health of Animals Act and Regulations. SYNONYM OR CROSS REFERENCE: MRSA (methicillin-resistant Staphylococcus aureus), MSSA (methicillin-susceptive (or sensitive) Staphylococcus aureus), VISA (vancomycin-intermediate Staphylococcus aureus), hVISA This Statement of Administrative Intent (SAI) is intended to clarify under which circumstances cells or cell lines are controlled under the authority of the Human Pathogens and Toxins Act (HPTA). ), Biosafety in Microbiological and Biomedical Laboratories (BMBL) (4th ed. Depending on the level, laboratory staff will have to possess a certain set of skills for handling potentially dangerous material. Canadian Biosafety Handbook CBS Canadian Biosafety Standard CFIA Canadian Food Inspection Agency CL Containment Level (i. Let’s break down each level: Biosafety Level 1 (BSL-1): Basic Lab Safety. Stanford University follows the categorizing of infectious agents into levels as described in Biosafety in Microbiological and Biomedical Laboratories (BMBL), 5th edition, written and published by the Centers for Disease Control (CDC) and NIH. Dec 24, 2024 · As part of its COVID-19 rapid collaborative response actions, the Biosafety Level 4 Zoonotic Laboratory Network (BSL4ZNet) is organizing a COVID-19 Research Symposium Miniseries from August 12 to September 16, 2020. 3 The Biosafety Study with Quizlet and memorize flashcards containing terms like BSL - 1, BSL - 1, BSL - 2 and more. L. suis) SYNONYM OR CROSS REFERENCE: Brucellosis, Undulant fever, Bang's disease, Malta fever, Mediterranean fever CHARACTERISTICS: Gram negative cocci or small rods, aerobic, non-motile, urease + Biosafety levels provide a structured approach to ensure the safety and containment of infectious agents in laboratories. Upon infection, the virus affects the host blood These Pathogen Safety Data Sheets, regulated under Workplace Hazardous Materials Information System (WHMIS) legislation, are produced for personnel working in the life sciences as quick safety reference material relating to infectious micro-organisms. More information on medical surveillance is available in the Canadian Biosafety Handbook. Containment Level Containment Level 1: Physical Design and Operational Practices guideline provides risk-based biosafety recommendations for facilities handling Risk Group 1 (RG1) biological material. About this site BioSafety Levels established to provide necessary precautions when working with biological organisms, especially infectious agents; each BSL covers general types of organisms classified within that level and establishes guidelines for handling those organisms PATHOGEN SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT. Given the state of Winnipeg, Manitoba, Canada . In the USA, the level of containment ranges from BSL-1 to BSL-4 by the Centers for Disease Control and Prevention (CDC). Human Pathogens and Toxins Act. At minimum, use of full body coverage dedicated protective clothing, dedicated protective footwear and/or additional protective footwear, gloves when handling infectious materials or animals These standards comprise four biosafety levels (BSLs) that typically apply to biological materials. E-Learning Courses. B Biosafety and Biosecurity), Canada Dr Catherine Makison Booth, Health and Safety Executive, United Kingdom of Great Britain and Northern Ireland Ms Michelle McKinney, Centers for Disease Control and Prevention (WHO Collaborating Centre for Biosafety and Biosecurity), and National Institutes of Health, Different countries have defined biosafety levels in their own way. As part of its COVID-19 rapid collaborative response actions,the Biosafety Level 4 Zoonotic Laboratory Network link to new page 1 (BSL4ZNet) is organizing a COVID-19 Research Symposium Miniseries from August 12 to September 16,2020. Containment / Containment Levels. The descriptions of biosafety levels (BSL) 1 – 4 parallel those in the NIH Guidelines for - Lowest biosafety level 1/Low Risk Microbes (BSL-1) - Highest at level 4/High Risk Microbes(BSL-4) - In the USA: the Centers for Disease Control and Prevention (CDC) have specified these levels. 88-117). : Centres for Disease Control and Prevention IMMUNIZATION: Formalin inactivated vaccine (JE-VAX) is licensed in Canada and recommended for those of increased risk such as laboratory workers and travellers spending more than one month in endemic/epidemic areas during the transmission season; Biosafety level 3 practices, containment equipment, As of April 1, 2023, the Canadian Biosafety Standard, Second Edition (CBS2) is no longer in effect. BSL-1 is the lowest biosafety level, suitable for work with well-characterized agents that pose minimal risk to healthy adults. viii Canadian Biosafety Standard ABBREVIATIONS AND ACRONYMS Ag Agriculture (i. CONTAINMENT REQUIREMENTS: Containment Level 2 facilities, equipment, and operational practices for work involving infectious or potentially infectious materials, animals, or cultures (). 3 The Biosafety The Government of Canada's Canadian Biosafety Standard (CBS), 2nd Edition, 2015, is a harmonized national standard for the handling or storing of human and terrestrial animal pathogens and toxins in Canada. PROTECTIVE CLOTHING: Laboratory coat; gloves should be worn during necropsy of infected animals and when contact with infectious materials is How to use this tool How to use this tool. At minimum, use of full body coverage dedicated protective clothing, dedicated protective footwear and/or additional Abbreviations BSC biological safety cabinet CFIA Canadian Food Inspection Agency CL1 containment level 1 CL2 containment level 2 CL3 containment level 3 CSA Canadian Standards Association HC Health Canada HEPA high efficiency particulate air HPIR Human Pathogen Importation Regulations HVAC heating, ventilation and air conditioning ICAO International Civil A UV-A radiation energy level of 1000 µW/cm 2 for 90 minutes and 20 µg/mL of 4'-aminomethyl-trioxsalen as well as an overarching risk assessment of the biosafety program as a whole. CHARACTERISTICS: Clostridium tetani is a motile, anaerobic, spore forming bacteria (terminal spores with drum stick appearance) Footnote 1, Footnote Biosafety Guidelines . e. Footnote 1. Government of Canada, Second Session, Fortieth Parliament, 57-58 Elizabeth II, 2009, (2009). New and emerging influenza A viruses (Alphainfluenzavirus influenzae) (November 15, 2024) Regulatory information: The import, transport, and use of pathogens in Canada is regulated under many regulatory bodies, including the Public Health Agency of Canada, Health Canada, Canadian Food Inspection Agency, Environment Canada, and Transport Canada. Select up to three search categories and corresponding keywords using the fields to the right. Users are responsible for ensuring they are compliant with all relevant acts, regulations, guidelines, and standards. Footnote 2. , boots, shoes) or additional protective footwear (e. In Best M. NAME: Aspergillus spp. NAME: Streptococcus pneumoniae. Andrin, A. Our mission is to help the people of Canada maintain and improve their health. 2 Overview. Advanced Search. Return to footnote 28 referrer MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT. We will communicate the publication of these updates through the Biosafety and Biosecurity for Pathogens and Toxins News. The cost for building a Biosafety Level 4 (BSL-4) facility is exorbitant; such a facility is also very expensive to operate and maintain. 6. , CL2 large animal containment zone) CL3-Ag CL3 Agriculture (i. Army Medical Research Institute of Infectious Diseases it includes information on the different levels of containment laboratories (Biosafety levels 1-4), and about their packaging when about biosecurity Ira L. Management of these risks necessitates an awareness and application of biosafety and biosecurity practices among personnel in laboratories and other containment zones where work with pathogens, toxins, infectious material, or infected animals Biosafety levels dictate the type of work practices that are allowed to occur in a lab setting and play a huge role in the design of the facility. ; As part of its COVID-19 rapid collaborative response actions, the Biosafety Level 4 Zoonotic Laboratory Network link to new The number of biosafety level 4 (BSL4) maximum-containment laboratories (facilities) worldwide has increased significantly.
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