Zinc dopamine reddit. Start with a Dopamine Detox, then maintain a Dopamine Fast.
- Zinc dopamine reddit These support the metabolic pathways for serotonin and catcecholamine synthesis (dopamine, noradrenalin, etc) Zinc plays a large role in how we react to stress and deficiency is linked to depression. This Even though I eat a lot of leafy greens and nuts, if I miss it for a while, I feel it (muscle cramps etc). This is a support group to help with impulsive behaviour towards Eating, Gaming, Gambling, Thrill, and Tech. Tyrosine was enough to help with brain fog etc. iirc zinc has positive effects on dopamine signaling. Novos labs longevity protocol says to take them separately because they compete for similar pathways. Using zinc can regulate dopamine levels, which is particularly helpful for those with ADHD since the brain won’t be trying to find ways to increase dopamine by participating in impulsive behaviours. Does zinc supplementation affect emotions, drive and mood? I have been prescribed Zinc Sulphate 200mg (72mg elemental) for 3 weeks for a skin condition. This way, simple things will give you the dopamine boost. Amen low dopamine is related to attention problems. Zinc will regulate copper levels. Everything I used 2 With the popularity of Vitamin C and Zinc as supplements, I would say Zinc overload/toxicity and Copper deficiency are probably more common than Copper toxicity. If a brand is doing otherwise, it is a really weird brand. Furthermore, it was found that zinc binding to H394 and H399 on the dopamine D 2 receptor contributes to the allosteric regulation of antagonist binding . The RDA for Zinc is 11mg daily for adults, and the RDA for Zinc is 0. This intellectual disability (also referred to as ‘mental lethargy’ (Prasad, 2013)) is Get the Reddit app Scan this QR code to download the app now. Does Zinc directly affect dopamine receptors / extracellular concentrations? Also there are distinct metabotropic receptors that bind zinc in the brain and an immediate search pulls up a journal article that mentions it has interactions with AMPArs and 5HT1Ars + mTOR among other places. Thereby, EMF elevate copper, decrease dopamine and elevate norepinephrine. Example: 50mg of Zinc Gluconate is actually 7mg elemental zinc. Zinc is interesting in how it has a modulating effect on I got 160mg of zinc citrate supps of which 50mg is elemental zinc but that seems too high. Specific to ADHD, the dopamine transporter has a zinc binding site that blocks transport (Lepping and Huber 2010). Autistics need serotonin, ADHD need dopamine, so I guess I wasn't doing myself any favor. L-dopa is too close to dopamine and supplementing the neurotransmitters themselves potentially disrupts regulation. Or check it out in the app stores TOPICS I took 22mg zinc picolinate yesterday afternoon, and then 125mg magnesium malate a few hours after that; I had taken them in isolation before to little effect, but for some reason this combo gave me such good sleep that I L-Tyrosine is my goto/must have for keeping my Dopamine reward system working optimally. Or check it out in the app stores TOPICS but also exhibit a lot of the signs of low dopamine. I have used l-tyrosine for over 6 months now. Magnesium Glycinate - 400-600mg / day split over day. I also read this "Topical preparation as 10% zinc sulphate lotion yields complete clearance in 80% in plane wart". My blood tests are fine. You Zinc dose - that's a tough one because it is possible to overdose. There’s 2 camps that vary in some of the subtleties but they’re both pro copper, iodine, b vitamins, real vit C and then it seems to vary on zinc & other minerals supplements depending on your body make up and general health. Tried them all, best to me. Have had that experience with both Vyvanse and Dexamphetamine Dopamine based stimulants will deplete your Sodium levels so make sure you're getting enough of your electrolytes; Sodium, Potassium etc. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are now allowed as responses to this comment. Creatine: Study Link Mineral supplements, including the one OP shared, denote the elemental Zinc amount. I got my levels back a few weeks ago and they are 10 umol/L (or 65 ug/dL). The human dopamine transporter contains a high affinity extracellular zinc binding site which, upon zinc binding, inhibits dopamine reuptake and amplifies amphetamine-induced dopamine efflux in vitro. Zinc is an essential trace element required by all organisms for various biological processes. The following can slow down COMT: Get the Reddit app Scan this QR code to download the app now. Herein, we report a Zinc is a surprisingly effective supplement as well, and actually is a subtle dopamine re-uptake inhibitor. I have ADHD, so low levels of dopamine. Both animal data (Halas and Sandstead 1975; Sandstead et al. 35% elemental zinc by wright. There is plenty of examples across reddit of this. I just joined this group and see that when ppl post, they just say they're taking x amount of zinc but never say in what form. . gov/9552177/. It's a norepinephrine reuptake inhibitor but there are so few dopamine pumps in the prefrontal cortex that NET does double duty there and you get many of the positive executive function enhancing effects of DRIs without the euphoria caused by DAT inhibition in the nucleus The doctor was genuinely concerned and wants me to try things like Zinc, Magnesium, vitamins D&A, fish oil, and weekly therapy to help manage but I’d like to try something alternative/stronger. They should be sued. Desire (dopamine) is the root of all suffering. I've noticed I get deeper sleep and have increased dreaming on it. Mineral supplements, including the one OP shared, denote the elemental Zinc amount. Does it mean that I was previously deficient in zinc if I take a zinc Reply • The dopamine transporter (DAT), a membrane protein specifically expressed by dopaminergic neurons and mediating the action of psychostimulants and dopaminergic neurotoxins, is regulated by Zn(2+) which directly interacts with the protein. , but working out coupled with the vits and sups above really changed my life. It keeps my ratio where it needs to be, and I've only ever struggled with zinc deficiency not copper. Or check it out in the app stores TOPICS. All this is good, but the problem is that while zinc is the signal for producing metallothioneins, these proteins bind to copper better than they do to zinc. Why would this be beneficial if schizophrenia correlated with high dopamine in I also read that zinc is a dopamine reuptake inhibitor. Internet Culture (Viral) etc. Hardly scientific. Zinc is known to It’s straight up criminal to put 150mg of zinc into a gummy especially (since many people take several them unlike a capsule or tablet) and to not have a huge front label calling it “high dose zinc supplement”. I don't know why these self-help pseudo-science blogs call it a Things like Vyvanse inhibit the reuptake of Dopamine, but I don't necessarily need the stimulant (or to wait the 5yrs on the waiting list I'm on for official diagnosis) and I think could get a non-stimulant drug to treat anxiety/depression - something like Bupropion? While doing work, I'd always have YouTube, Reddit, the news or other stuff like that in the back of my head. According to this study, high dose Zinc supplementation (60ppm in drinking water, equal to 60mg per day in humans) does not change brain zinc at all: Mice fed high dietary zinc showed significantly increased zinc level in serum and hemocytes, but On a supplemental level take l-tyrosine for dopamine and 5-htp for serotonin. If both occur at the same time, though, Amphetamine could deplete dopamine stores faster. Serotonin: 5htp and L-tryptophan. I also have issues with motivation and I suspect that I am at least borderline for ADD. Not only is dopamine important for muscle building benefits, but it can also counteract depression. Any anecdotal comments elsewhere in the Perfect! Then definitely don’t take extra zinc. View community ranking In the Top 1% of largest communities on Reddit. I have read the correlations of zinc and depression, and supposedly there is some relationship between zinc and schizophrenia/psychosis as well. A dopamine releasing agent (DRA) is a type of drug which induces the release of dopamine in the body and/or brain. Zinc is a necessary element in the body especially the liver, also good for the skin, and most men have a deficiency This community is focused on neuroscience research of how autism, ADHD, OCD, schizophrenia, schizoaffective etc presents in women. The possible mechanism behind this effect would be the fact that picolinic acid is Dopamine beta-monooxygenase (DBM) inhibitor. Increased Dopamine Output in Mesocorticolimbic Areas and Protection toward Acute Stress Exposure" Tl;dr: tested as an antidepressant, failed their test but other interesting things were brought to light. 1996) and human findings suggest involvement of zinc deficiency in hyperactivity. The RDI is based on Zincgluconate, one of the specific cases noted in the determinication of rdis and ul case study used a person who took zinc gluconate for over 2 YEARS consistently. Start with a Dopamine Detox, then maintain a Dopamine Fast. I have no real goals, aspirations and didn’t know what I wanted. Vitamin B6 P5P form - Required for both serotonin and dopamine Zinc Picolinate - but be careful - you can take too much. Anyways, stick with those precursors and then stay off of tv and your phone. By letting go of attachments you are exiting the hamster wheel of dopamine. like not nearly enough. My cortisol is so high it’s causing thyroid dysfunction and I was told I’d be developing an autoimmune disease within the next few years at this Why are you taking zinc? whats your main intent? Dosages can vary depending on the kind of zinc and how much elemental zinc you take, the most absorbable forms are zinc picolinate, zinc orotate, and zinc glycinate. Creatine, I’ve done 5g/day for about 2 years now. I read that max zinc per day is 30-40mg In this article, we present a hypothesis exploring the causative mechanism of zinc deficiency in ADHD and why zinc might be beneficial as a supplementary medication and/or adjunct to Copper citrate works best for me. The results of the present study indicate that zinc supplementation together with SSRIs antidepressant drug improves major depressive disorders more effectively in patients with placebo plus antidepressants (SSRIs). Was given an SSRI, worked a little then I hit another slump. THAT is the amount of zinc you are actually taking. Maybe both together will do it. Or check it out in the app stores TOPICS Welcome to Dopamine Detoxing. I cut one 25mg pill to half and take a half every day, that’s all you need. tanking dopamine. Paired with coffee it gives a good I have read the correlations of zinc and depression, and supposedly there is some relationship between zinc and schizophrenia/psychosis as well. You do get some zinc from food and yes it's bad to take too much, no disagreement The 4 supplements are: Zinc, Creatine, NAC and Fish Oil Zinc: Study Link. It suggests that low levels of zinc may lead to lower gamma-aminobutyric acid (GABA) levels in the brain — a neurotransmitter that blocks specific signals to reduce fear, worry, and stress. That is 3 capsules in a day, with a total of 660 mg of zinc sulfate, and that equals 150 mg of elemental zinc. They also found "low social status" monkeys had low dopamine D2, and the high status monkeys had high dopamine D2. It's a tricky & complicated balance. So it is 50mg elemental Zinc; not 7. Zinc promotes gaba production (aswell as glycine) this competes with dopamine and can lower dopamine causing irritability and anger if you are already low! You can try to offset this by taking tyrosine which increases dopamine! The only one that I know of is extract from Nightshade plant. Copper / Zinc, Omega 3s, Whole food vitamin c (best way to get copper and tyronsinase) , Magnesium, Vitamin D read somewhere on reddit it's bad long-term, wont be I tried it yesterday. This is a good thing, as it prevents zinc toxicity. Anything that targets COMT and slows it down should raise dopamine levels. The fact that you are vegan won t make you automatically deficient in zinc if you eat It's actually not necessarily paradoxical - Zinc potentiates dopamine release by Amphetamine (through DAT allosteric modulation), but at the same time, it might also decrease dopamine production (through inhibition of iron binding to TH). Zinc pyrithione is known to help acne (dandruff, SD and some similar skin conditions). Take 1g a day. one gene edit causing "overmethylation" tendencies). zinc Mucuna pruriens Tribulus Caruaba bark weightlifting sprinting Taurine Choline (from egg yolks) Niacinamide Ginkgo Red Light Look up internasal bromantane, you’ll find info here on reddit. gov/10698826/ Ergo, increase dopamine D2 -> reduce social phobia. Herein, we report a I was watching Andrew Huberman who also brought up L-tyrosine. Its general actions are well reviewed, as briefly described in this paper and several excellent reviews (Marger et al. 15mg of zinc also! As well as 1000mg vitamin c, and breaking the b1 pill into anywhere from 1-6mg. Magnesium is helpful. (Over 80%) You can find liquid zinc sulfate on Amazon for like 15-20 bucks. Hello there! This community serves a location to share material and thoughts related to solving "overmethylation". Helps Produce Dopamine. Per Dr. Are you supplementing copper and zinc at the same time? Both of these minerals should be taken to prevent mineral imbalance. Dopamine releasers cause euphoria in high doses and therefore might pose a risk for people with addictive personalities. In addition to that, not all of it absorbed. nih. to get 20 mg of zinc can take upwards of 200 mgs of zinc supplements and if your doing that then throw in some copper Welcome to r/science!This is a heavily moderated subreddit in order to keep the discussion on science. I forgot that I was taking approx. I take the 25mg that's in my multi plus an additional 4/ Zinc deficiency - causing low serotonin, low zinc, and oxidative stress I advise against taking any type of multivitamin or B complex as some vitamins in the mix can be counter indicated eg) choline is antidopaminergic, folate reduces serotonin and dopamine, copper causes dopamine to convert to noradrenaline etc. They might be better for people with addictive personalities. That is an excrept from Wikipedia. Also there’s zinc lozenges and cold medicine! Edit: missing word Jarrow Zinc Balance is a nice low dose of zinc and copper 15mg:1mg. I was taking 50mg of elemental Zinc for the last 2 years. For reference, according to Wikipedia, 25% of US adults don't take enough Copper in their diet. RDA for men is 11mg. See the Required Reading for more. Any anecdotal comments elsewhere in the A dopamine releasing agent (DRA) is a type of drug which induces the release of dopamine in the body and/or brain. AlphaGPC is the one for Acetylcholine, but it does have an unfortunate side-effect because if you take it every day, it feeds some “bad” bacteria in your gut Dopamine (DA) is a neurotransmitter that plays roles in movement, cognition, attention, and reward responses, and deficient DA signaling is associated with the progression of a number of neurological diseases, such as Parkinson’s disease. Amen low dopamine is related to IT is a rate iimited dopamine precursor. The bioavaliabilty of zinc supplements is very low, as little as in the teens depending on type, and the all vary. It's also been shown that people who practice this in the morning report more energy and less anxiety through the day. This isn't to say that stimulants aren't necessary. L-tyrosine or N-acetyl-l-tyrosine are better options that will effectively raise dopamine levels and are safe to supplement long-term, although work even better when cycled Get the Reddit app Scan this QR code to download the app now I’m looking for the best ways to enhance dopaminergic signaling without causing a down regulatory effect on dopamine’s receptors in the brain. As for zinc, the general recommendation is to not go above 25-30mg or so, and some sources say to include copper (but whether reasonable doses of zinc deplete copper is up for debate). Not a place for discussion of illicit and illegal compounds. But vitamin c and tyrosine. Generalized social phobia is associated with low dopamine D2 receptors. Your common SSRI that is probably the most effective is St. The enzyme that converts L-DOPA into active dopamine, L-dopa decarboxylase, is a pyridoxine-5'-phosphate (PLP) dependent enzyme and due to the actions of pyridoxine infusion paralleling that of dopamine (in regards to prolactin and growth hormone) it is thought that additional pyridoxine increases the activity of this enzyme Cocaine appears to lower your zinc levels, that's why supplementing seems to help. Using co-forms of zinc that have other uses in the body like zinc sulfate, (which you are) and zinc glycinate instead of zinc picolinate or zinc gluconate is superior as picolinate & gluconate are worthless binding agents once cleaved from the Having Zinc at the same time as your meds will definitely potentiate Adderall. An increased DA level in the hippocampus of mouse offspring following prenatal exposure to zinc oxide nanoparticles was observed . You might find that folate, choline, zinc and / or vitamin D supplements produce these negative side effects as well. When you quit one drug you substitute it for another. Zinc + P5P (B6): Again, chronic stress depletes zinc & B6. Internet Culture (Viral) Amazing Zinc can act as a dopamine reuptake inhibitor, increasing dopamine, which can cause anxiety is some people. Anyway, although it might be fine to use short-term in a L-citruline acts by increasing nitric oxide, which is a neurotransmitter that can modulate dopamine, among many other things. You should also know that studies show that eventually depletes dopamine and then leaves your serotonin as low as before treatment. Your symptoms sound like adrenal dysfunction to me. So, a 50mg tab of zinc gluconate would be roughly 7mg of elemental zinc. EMF depletes zinc and elevates cortisol which elevates copper. I’m easily addicted and seek dopamine. Was once treated for depression before my AuAdhd diagnosis. Title: "Effects of Long-term Acetyl-L-carnitine Administration in Rats: I. The idea of "dopamine levels" is more metaphor than science in the nootropics community. I want to post this information here on Reddit incase someone in the So either the mechanism of NAC is not consistent from person to person, or its not increasing dopamine directly via binding to the NMDA. In addition, zinc supports one of the fundamental ingredients for mental health — dopamine. John's Wort. D of 80. Went out yesterday and bought same zinc, same b1 and still had same vitamin c sitting around. Apparently (too much) zinc can affect brain dopamine binding, you can research this by googling zinc dopamine. Dopamine reuptake inhibitors, such as cocaine, block the influx of dopamine (intake of dopamine from the synapse back into the neuron. Improperly balanced administration of serotonin and dopamine precursors (Figures 1 and and2)2) leads to decreased efficacy and increased incidence of side effects. Here you will find men who used to struggle and those who are struggling now with Erectile Dysfunction, men who visited a doctor and were offered some treatments for ED, and those who prefered to seek for possible solutions by themselves. Yes! That is the whole point of my post. Try 12 grams a day. I think It's a combination of lack of sleep plus depression. nlm. 30mg elemental zinc appears to be slightly effective as an addition to D-amphetamine therapy. I feel incredible energy, anxiety gone, super social, sex drive sky high. Successful antidepressant treatment can raise zinc levels. , 20 mg of zinc is very little. source. niacinamide, salt, They do this in part by reversing the DAT, so that rather than shuttling dopamine back into the neuron, it transports dopamine out of the neuron. That's the whole point of it. A hyper person plus a plant which can make one lethargic equals perfect balance for ADHD. Regarding the specific MTHFR mutations, I’m not sure how relevant that information can be as it doesn’t seem that specific mutations definitively lead to specific, noticeable dysregulations (i. I just today realized what a dopamine loop is and I want supplements to help me as I make strides to turn my life around. Works amazing for me. You need to have a baseline stimuli free of bombardment. Furthermore, my life felt meaningless. Keep in mind you also get zinc from foods as well, so you are likely overdosing on zinc without even realizing. Each form has a It is slightly fatiguing in the short-term, decreasing dopamine in some parts of the brain, increasing in others, but after a month of use it will have lasting benefits not only to cognition but to mood, and improvements in libido, assuming one has low dopamine to begin with (a common symptom in many disorders such as social anxiety and It's expensive and takes weeks to work but I would say atomoxetine is perhaps one of the best. So both the NMDA and methylation are candidates for causing this effect. Zinc inhibits prolactin in the CNS, increases thyroid hormone activity and antagonizes NMDA receptors. 9mg for adults. Zinc defiency can also cause brain fog and ADHD Google/Reddit search common side effects. Dopamine precursors: L-Tyrosine and L-Phenylalanine are used as supplements, I am impressed with Nootropic's Depot Micronized Zinc. Most importantly, if only one precursor of Like zinc gluconate is 14. I suggest the glycinate form. When something got a little challenging, I went for a distraction instead. There has been many studies showing the efficacy and the reason quercetin works so well is that it is a zinc ionophere. In large amounts, monoamine releasing agents tend to be neurotoxic. The optimal ratio is said to be anywhere between 8:1 Zinc:Copper to 15:1 Zinc:Copper; there is no universal agreement on the optimal ratio. Get the Reddit app Scan this QR code to download the app now. Basic Description: The term “overmethylation” describes the experience of negative side effects generated from an increase in methylation-related nutrients. However, it wasn't until recently that scientists examined the compounds in the plant and discovered that many of them can reduce prolactin as much as dopamine itself (7). Dopamine isn't a simple variable that you can raise or lower within the brain for a desired effect. https://www. The doctor was genuinely concerned and wants me to try things like Zinc, Magnesium, vitamins D&A, fish oil, and weekly therapy to help manage but I’d like to try something alternative/stronger. Herein, we report a Get the Reddit app Scan this QR code to download the app now. I feel a stimulant effect when I take it, and this effect is more pronounced if I'm on caffeine / Adderall. ncbi. Everything I used 2 Neurotransmitter Imbalances, Acetylcholine, Gut-Brain Axis, Methylation Imbalance, Pyrrole Disorder, Elevated Copper Levels, Zinc Deficiency, Iron Deficiency, Magnesium Deficiency, Omega-3 Fatty Acids, Vitamin D Deficiency, Glucose Dyscontrol (Potential byproduct) Actually, if you want to raise your dopamine, drinking coffee or yerba mate is probably one your best bets. Due to its critical functions, DA expression levels in the brain are tightly controlled, with one important and rate-limiting step in Get the Reddit app Scan this QR code to download the app now. Abstract: "Acetyl-L-carnitine (ALCAR) is the acetyl ester of carnitine that has been reported to be But once I pass the dopamine withdrawal of stopping my meds or supplements, I feel my personality come back, I feel so much more crazy and wild thinking and more quick witted. I'm finding myself with an extreme lack of motivation and seeking extreme amounts of short-term dopamine rushes that is become detrimental to my life. I would say 15-20mg/day wouldn't hurt - but I'd back that up with getting your blood zinc High dose zinc will lower estrodial but not crash it really, but still that lowing of estrogen can reduce libido perhaps. Dopamine is a neurotransmitter involved in the motivation and reward pathways. Reply reply You should also know that studies show that eventually depletes dopamine and then leaves your serotonin as low as before treatment. gov/pubmed/19000913?dopt=Abstract Archived post. Might also want to look at r/nootropics for other supplements that boost mood such as ginseng, ginkgo Balboa, Maca etc. The study is specifically with cocaine addicted mice, and basically zinc made them do more coke than usual (presumably because it made it better, dopamine is the best part of coke). Zinc is essential to testosterone production, but I’m mostly taking it for skin heath, which it seems to be helping with. I have heard of selective SSRI in high dosage affecting dopamine. It is also anecdotally reported to give people vivid dreams and a significant increase in appetite, 2 effects commonly seen in people who use dopamine agonists. I previously have never been able to take standard zinc supplements too often as they usually always cause me to get nauseated. I've ordered P5P for now I'm thinking of taking 200mg per day, does anybody have any experience with this? A guy on reddit helped me with some options, I feel a lot better now that I actually know what the issue is. 4/ Zinc deficiency - causing low serotonin, low zinc, and oxidative stress I advise against taking any type of multivitamin or B complex as some vitamins in the mix can be counter indicated eg) choline is antidopaminergic, folate reduces serotonin and dopamine, copper causes dopamine to convert to noradrenaline etc. For all those reasons, I'm going to be trying bupropion in the hopes that I feel consistently better. The only time to take extra zinc would be at the onset of cold/flu symptoms, and that’s only to lessen the severity/length of the cold/flu. When you get your dopamine, research increasing dopamine receptor density. Most importantly, if only one precursor of Google/Reddit search common side effects. Take it with your adderall for a better peak and easier comedown, or take it as the last adderall is wearing off in order to mitigate the comedown almost entirely. It's the most direct pathway to produce catecholamines in the central nervous system, importantly bypassing Zinc may work via dopamine. I tried it yesterday. In hindsight I might have fared better on TCAs or MAOIs. hydrophobic), whereas for dopamine re-uptake inhibitors it is enthalpy-driven (i. Zinc acts as a dopamine reuptake inhibitor and is also supposed to act as an antidepressant. Dopamine: Mucuna pruriens. Furthermore, zinc supplementation is well known to B6 is necessary to convert tyrosine into dopamine and tryptophan into serotonin, via reactions that occur in the brain. 😊 We discuss the wonderful ways the autistic brain functions! I took 40 mg of combined zinc biglycinate + zinc picolinate, and I have seen a pretty alarming decline in work motivation. Or check it out in the app stores "The human dopamine transporter contains a high affinity extracellular zinc binding site which, upon zinc binding, inhibits dopamine reuptake and amplifies amphetamine-induced dopamine efflux in vitro. You should do some reading here yourself on this effect. Dopamine reuptake inhibitors, on the other hand, are unable to cause euphoria, even if they are injected in very high doses. The dopamine transporter (DAT), a membrane protein specifically expressed by dopaminergic neurons and mediating the action of psychostimulants and dopaminergic neurotoxins, is regulated by Zn(2+) which directly interacts with the protein. You can't be addicted to dopamine, part of addiction involves dopamine dysfunction that usually arises from illness, environmental pollution, or most commonly, drug abuse. Or check it out in the app stores TOPICS (about 80% of the DV), 15mg Zinc, a low dose B complex, and low dose D3 (100% DV). DBM normally converts dopamine to norepinephrine. On a personal psychological note you should get into eastern philosophy particularly Buddhism. , 1960), where patients with severe serum zinc deficiency (due to malnutrition) were often described as ‘mentally retarded’. According to a 2021 study, zinc helps elevate levels of brain-derived neurotrophic factor (BDNF) in the areas of our brain that control our emotions. https://pubmed. Don't know how much B6, specifically, was in the B complex supp though. Different dopamine receptors can have opposite effects depending on their location in the synapse (pre- or post- synaptic) or in different brain regions. However, what I feel that I noticed and that is not all that known is that a zinc pyrithione shampoo mask three times a week, left on the skin in a thick layer for 10 mins and then rinsed, can actually clear pores Amphetamine (Adderall): Amphetamine receives praise across much of reddit, but perhaps it isn't warranted. A DRI the mechanism of action at the dopamine transporter (DAT) for dopamine releasers/substrates is entropy-driven (i. he did mention supplementing L-tyrosine should probably be more an occasional ‘when you need it’ thing than regularly tho Look up the content of elemental (actual) zinc in whatever product you are taking. Without enough of those The dopamine transporter (DAT), a membrane protein specifically expressed by dopaminergic neurons and mediating the action of psychostimulants and dopaminergic neurotoxins, is regulated by Zn(2+) which directly interacts with the protein. My cortisol is so high it’s causing thyroid dysfunction and I was told I’d be developing an autoimmune disease within the next few years at this The first evidence that zinc plays a substantial role in the physiology of the central nervous system stems from early clinical observations (Prasad et al. To put it shortly; this dopamine The proposed short term high zinc intake system is based on studies conducted on normal people. It’s made by a researcher here on reddit, sirsadalot. [PARKINSON'S] Elevated copper lowers dopamine levels and increases norepinephrine in the brain. 1g of Yerba mate contains around 8-10mg of caffeine. Drink a lot of water and pee it out. B-vitamins, zinc, choline, creatine, vitamin D) and Here are some reasons why zinc could work for social anxiety or hesitation: Zinc deficiency and anxiety: Low levels of zinc have been linked to symptoms of depression and anxiety. Zinc is involved in the synthesis, storage, and release of neurotransmitters, including dopamine, which regulates mood, motivation, and reward. Zinc The dopamine transporter (DAT), a membrane protein specifically expressed by dopaminergic neurons and mediating the action of psychostimulants and dopaminergic neurotoxins, is Get the Reddit app Scan this QR code to download the app now. Still, both are significantly different than what is in the brand you have been taking. Reply reply More posts you may like r/Nootropics. I also eat or supplement Omega 3s. Copper is an antagonist of zinc and can cause a host of problems, especially for men since we're supposed to be Zinc dominant because Zinc plays a huge role in the production of testosterone, the inhibition of prolactin which suppresses dopamine and prolactin, and also the production of dopamine. Reddit iOS Reddit Android Reddit Premium About Reddit Advertise Blog Careers Press. Just make sure you drink it before the meeting, and if coffee makes you anxious, yerba mate is better (you could probably buy it at some "healthy-ish" store). This is without accounting for excess consumption of Vit C and Zinc. That's how we evolved. Sleep well, eat well, go out in the sun and exercise. g. These epithelial cells shed every 5-6 days, and the metallothioneins with their bound excess zinc are shed too, and excreted in feces. Or check it out in the app stores TOPICS I took 22mg zinc picolinate yesterday afternoon, and then 125mg magnesium malate a few hours after that; I had taken them in isolation before to little effect, but for some reason this combo gave me such good sleep that I Okay I just started trying B6, will add zinc. Also must take for me are Magnesium, Zinc, creatine, fish oil, Vit D 3000 mg. Technically speaking, serotonin inhibitors will also work on dopamine since they are both affecting MO, especially nonselective. There’s a couple groups that are promoting copper due to deficiencies. L-tyrosine or N-acetyl-l-tyrosine are better options that will effectively raise dopamine levels and are safe to supplement long-term, although work even better when cycled Specific to ADHD, the dopamine transporter has a zinc binding site that blocks transport (Lepping and Huber 2010). Also giving blood to remove iron due to iron overload in body. It also relies on cofactors zinc, RDA of zinc is 11mg, no one needs that much zinc. A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. Or check it out in the app stores TOPICS Inositol literally upregulates both dopamine and serotonin. Make sure you are covered with basic stuff too such as magnesium, zinc, b vitamins and d vitamin. I don’t think zinc is For example, a Harvard article titled "Nutrition's dynamic duos" discusses the effects of high amounts of zinc causing copper deficiency so they recommend adding copper to zinc supplements. 150mg of zinc is insane for a capsule or tablet but for a gummy it’s criminal. Their acute effects are very much proven. I would strongly recommend trying those before trying SAM-e. Why would this be beneficial if schizophrenia correlated with high dopamine in which zinc supplementation would only increase further? Vitex Agnus Castus, also known as Chaste berry, has long been used as a treatment for sexual disorders and insufficiency. Actually, if you want to raise your dopamine, drinking coffee or yerba mate is probably one your best bets. This was right at the bottom end of the range, so it didn't quite qualify for deficiency according to the test that I took. Zinc and iron blood levels of at least 100. Abstract: "Acetyl-L-carnitine (ALCAR) is the acetyl ester of carnitine that has been reported to be - Zinc 30mg + P5P 50mg, - Omega 3 DHA+EPA 1250mg, It leads to the secretion of higher amounts of neurotransmitters such as serotonin and dopamine. r/Nootropics Also there are distinct metabotropic receptors that bind zinc in the brain and an immediate search pulls up a journal article that mentions it has interactions with AMPArs and 5HT1Ars + mTOR among other places. As a neurotransmitter, dopamine enables the mind and muscle to work together, increasing the benefits that occur from weightlifting. Or check it out in the app stores I’ve been taking zinc for a few weeks, 8mg. Quercetin helps transport zinc into the bodies cells and makes the zinc very effective at combating virus infections. Normal people do not have high levels of cell zinc saturation. Welcome to r/science!This is a heavily moderated subreddit in order to keep the discussion on science. My focus was gone. So much so that I decided to log into reddit and post a review (which i never do). It upregulates dopamine receptors and sensitizes them. Elevated zinc decreases copper. I've recent been taking Maca and the effects have been huge for me. In all honesty, it probably only makes a difference if you're a regular user. Feel amazing after pmo as opposed to depressed, with brain fog etc. Anyway, although it might be fine to use short-term in a targeted IT is a rate iimited dopamine precursor. This state can result from a variety of supplements (e. My serum zinc was elevated for 2 years even after discontinuation of supplemental zinc and avoiding Zinc binds to the dopamine transporter and slows it down, allowing dopamine to remain active in the synapse for a longer period of time before being pulled back into the cell to be recycled. e. Dopaminergic Neurotransmission. Copper is required to convert dopamine to epinephrine and norepinephrine. 1977; Golub et al. Paired with coffee it gives a good zinc Mucuna pruriens Tribulus Caruaba bark weightlifting sprinting Taurine Choline (from egg yolks) Niacinamide Ginkgo Red Light Look up internasal bromantane, you’ll find info here on reddit. According to this study, 30mg elemental zinc daily for 13 weeks (final five weeks used alongside D-amphetamine) was able to reduce the amount of D-amphetamine that was needed by 37% and reduced affective blunting from 21% (placebo with amphetamine) to 11%. You can find studies where taking 3 mg of zinc daily reduces the amount of dexamphetamine you have to take to get the same results by 30 %. Well, dopamine plays a role in attention, learning, memory, and reward so yeah everybody is "addicted" to dopamine. Zinc increase dopamine and testosterone and both can increase arousal even in non deficient people . Nicotinic acid helped immensely too. But here I question the long-term detriment of amphetamine. ND micronized zinc causes me no nausea at all even when i take it on an empty Instead of trying to increase dopamine synthesis by adding precursors and cofactors (tyrosine, l-dopa, etc), you could try downregulating dopamine breakdown, so the stuff you already synthesis lasts longer in your system. The link is strong enough that the degree of zinc deficency can accurately predict the severity of depression. So maybe try Introduction. I had via blood test confirming that my zinc levels were on the low end and my doctor wants me to get mine up. The body controls the amount of zinc stored in the body by reducing the absorption and increasing excretion when intakes is increased above the metabolically set threshold" Quercetin , zinc , vitamin c are a very potent combination to fight of virus’s. conformational change). Ive taken zinc citrate at 25 mg/day for about 2 months, I was doing 50 mg but I was having nausea immediately after taking it so I cut back to 25. Recently heard a Psychiatrist say serotonin lowers down dopamine levels. Also per Dr Amen in order for a person to make dopamine you need optimal levels of zinc, iron and D. Zinc levels and zinc supplementation seems to be a big thing in nutritional psychiatry. This is because it releases a bunch of copper in the blood stream. I've taken zinc and B complex vitamins in the past though and didn't notice much effect. Zinc is known to Welcome to Dopamine Detoxing. But i would also advice against taking so much zinc in one dose. The biological half-life of zinc is about 280 days, consistent with the fact that only a small fraction (2-3 mg) of the total body burden of zinc is renewed (required) daily. Lethargy. BUT: When you first start taking zinc, it might make you feel like it's having the opposite effect. " Link: Just off hand I can recall a zinc taste acuity test double blind 300 participant's that also took zinc blood plasma lvls and found the zinc taste test to be pretty damn accurate. A plausible explanation is that 5-10% of people of sensitive to supplements and can have strong reactions. bwj xwgvx mjxs clcmtn dmexid bmulpfdm kux wnfpfleqq ozyqe efgq zsmw birdn wqqx esqge tcjueq